Two new papers published

De-Orphanizing Marine Molecules
Nature Medicne Burua. Bioprosthetic heart valves calcification

The year is off to a positive start in terms of publications. Two new papers related to Burua Scientific have appeared. One of them even incorporates Burua Scientific in the authors’ addresses: the first official Burua publication!

In fact, both come from previous collaborations of our founder. He has been working in the industry for years, but fortunately has had the opportunity to continue collaborating and publishing. Collaborations, for him and for Burua, are fundamental. They are a way of transferring knowledge to society, of giving it back to the community. At the same time they allow to give visibilty to what we do; they help us to try to be at the forefront and at the same time to be judged for it. They allow us to have a more or less objective idea of the quality/validity of what we do for the scientific community. Therefore, they are basic for us.

We also have to bear in mind that we are not just a service provider. That we are, that’s true, but we also want to establish collaborations with companies and researchers in public and non-profit organisations to make disruptive discoveries. We believe that collaboration will allow us to have a greater impact on society.

In this sense, we have already established collaborations from Burua, which we hope will be as fruitful as those that gave rise to these publications.

Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases

The first paper, published in January, was Laura’s latest PhD work. It was the result of a fruitful public-private collaboration between the Universitat de Barcelona and the former Mind the Byte, which has yielded several interesting scientific results related to the potential of marine molecules, especially meridianins, as possible therapeutic agents in neurodegenerative diseases, in particular Alzheimer’s. 

This particular work is a further confirmation of the potential of CADD techniques in marine drug discovery, specifically the deorphanisation of marine molecules. Interestingly, due to the high access rate, the article is now displayed on the Marine Drugs home page!

 

The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

The second paper, published in February, is an article published by the Translink consortium. Translink was a large multidisciplinary EU-funded project with the aim to “Define the role of xeno-targeting and autoimmune events in patients receiving animal-derived bioprosthetic heart valves”.  

Bioprosthetic heart valves in humans calcify due to antibody immune responses to sugar antigens (Neu5Gc and alpha-Gal xenoglycans). However, the translink project has shown that the use of tissues from knock-out animals that do not express these glycans may be a solution to the problem, which is good news for the future.

In addition to the article, a brief summary of the results can be found.

All in all, a good start to the publishing year! Let’s hope for more successful publications and collaborations to come. 

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